TY - JOUR
T1 - Regulation of cadherin-mediated cell-cell adhesion by the rho family GTPases
AU - Kaibuchi, Kozo
AU - Kuroda, Shinya
AU - Fukata, Masaki
AU - Nakagawa, Masato
N1 - Funding Information:
We thank Naohiro Itoh and Aie Kawajiri for preparing the manuscript. The original work by the authors has been supported by the Japan Society of the Promotion of Science Research for the Future, by the Ministry of Education, Science, and Culture, Japan, by the Human Frontier Science Program, and by a grant from Kirin Brewery Company Limited.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion, IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and β-catenin and induces the dissociation of α-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.
AB - Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion, IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and β-catenin and induces the dissociation of α-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.
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U2 - 10.1016/S0955-0674(99)00014-9
DO - 10.1016/S0955-0674(99)00014-9
M3 - Review article
C2 - 10508646
AN - SCOPUS:0032859045
SN - 0955-0674
VL - 11
SP - 591
EP - 596
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -