Regulation of intestinal homeostasis by dendritic cells

Hiroyuki Tezuka, Toshiaki Ohteki

研究成果: Review article査読

40 被引用数 (Scopus)

抄録

The healthy gut consists of the commensal flora, the epithelial layer, and the gut-associated lymphoid tissues (GALT). The GALT need to be hyporesponsive to commensal and dietary antigens while possessing the capacity to detect and attack pathogens. Accumulating evidence suggests that dendritic cells (DCs) play integral roles in managing this paradoxical situation and maintaining the complex homeostasis in the gut, which includes the induction of immunoglobulin A (IgA) synthesis. This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in our understanding of how DCs are involved in IgA synthesis in the gut.

本文言語English
ページ(範囲)247-258
ページ数12
ジャーナルImmunological Reviews
234
1
DOI
出版ステータスPublished - 01-03-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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