TY - JOUR
T1 - Regulation of intestinal homeostasis by dendritic cells
AU - Tezuka, Hiroyuki
AU - Ohteki, Toshiaki
PY - 2010/3
Y1 - 2010/3
N2 - The healthy gut consists of the commensal flora, the epithelial layer, and the gut-associated lymphoid tissues (GALT). The GALT need to be hyporesponsive to commensal and dietary antigens while possessing the capacity to detect and attack pathogens. Accumulating evidence suggests that dendritic cells (DCs) play integral roles in managing this paradoxical situation and maintaining the complex homeostasis in the gut, which includes the induction of immunoglobulin A (IgA) synthesis. This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in our understanding of how DCs are involved in IgA synthesis in the gut.
AB - The healthy gut consists of the commensal flora, the epithelial layer, and the gut-associated lymphoid tissues (GALT). The GALT need to be hyporesponsive to commensal and dietary antigens while possessing the capacity to detect and attack pathogens. Accumulating evidence suggests that dendritic cells (DCs) play integral roles in managing this paradoxical situation and maintaining the complex homeostasis in the gut, which includes the induction of immunoglobulin A (IgA) synthesis. This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in our understanding of how DCs are involved in IgA synthesis in the gut.
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U2 - 10.1111/j.0105-2896.2009.00872.x
DO - 10.1111/j.0105-2896.2009.00872.x
M3 - Review article
C2 - 20193023
AN - SCOPUS:77349123232
SN - 0105-2896
VL - 234
SP - 247
EP - 258
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -