TY - JOUR
T1 - Regulation of microtubules in cell migration
AU - Watanabe, Takashi
AU - Noritake, Jun
AU - Kaibuchi, Kozo
PY - 2005/2
Y1 - 2005/2
N2 - Directional cell migration is a fundamental process in all organisms that is stringently regulated during tissue development, chemotaxis and wound healing. Migrating cells have a polarized morphology with an asymmetrical distribution of signaling molecules and the cytoskeleton. Microtubules are indispensable for the directional migration of certain cells. Recent studies have shown that Rho family GTPases, which are key regulators of cell migration, affect microtubules, in addition to the actin cytoskeleton and adhesion. Rho family GTPases capture and stabilize microtubules through their effectors at the cell cortex, leading to a polarized microtubule array; in turn, microtubules modulate the activities of Rho family GTPases. In this article, we discuss how a polarized microtubule array is established and how microtubules facilitate cell migration.
AB - Directional cell migration is a fundamental process in all organisms that is stringently regulated during tissue development, chemotaxis and wound healing. Migrating cells have a polarized morphology with an asymmetrical distribution of signaling molecules and the cytoskeleton. Microtubules are indispensable for the directional migration of certain cells. Recent studies have shown that Rho family GTPases, which are key regulators of cell migration, affect microtubules, in addition to the actin cytoskeleton and adhesion. Rho family GTPases capture and stabilize microtubules through their effectors at the cell cortex, leading to a polarized microtubule array; in turn, microtubules modulate the activities of Rho family GTPases. In this article, we discuss how a polarized microtubule array is established and how microtubules facilitate cell migration.
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U2 - 10.1016/j.tcb.2004.12.006
DO - 10.1016/j.tcb.2004.12.006
M3 - Review article
C2 - 15695094
AN - SCOPUS:13244269913
SN - 0962-8924
VL - 15
SP - 76
EP - 83
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -