Regulation of microtubules in cell migration

研究成果: ジャーナルへの寄稿総説査読

262 被引用数 (Scopus)

抄録

Directional cell migration is a fundamental process in all organisms that is stringently regulated during tissue development, chemotaxis and wound healing. Migrating cells have a polarized morphology with an asymmetrical distribution of signaling molecules and the cytoskeleton. Microtubules are indispensable for the directional migration of certain cells. Recent studies have shown that Rho family GTPases, which are key regulators of cell migration, affect microtubules, in addition to the actin cytoskeleton and adhesion. Rho family GTPases capture and stabilize microtubules through their effectors at the cell cortex, leading to a polarized microtubule array; in turn, microtubules modulate the activities of Rho family GTPases. In this article, we discuss how a polarized microtubule array is established and how microtubules facilitate cell migration.

本文言語英語
ページ(範囲)76-83
ページ数8
ジャーナルTrends in Cell Biology
15
2
DOI
出版ステータス出版済み - 02-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞生物学

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