Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7

M. Lagha, T. Sato, L. Bajard, P. Daubas, M. Esner, D. Montarras, F. Relaix, M. Buckingham

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Pax genes have important roles in the regulation of stem cell behavior, leading to tissue differentiation. In the case of skeletal muscle, Pax3 and Pax7 perform this function both during development and on regeneration in the adult. The myogenic determination gene Myf5 is directly activated by Pax3, leading to the formation of skeletal muscle. Fgfr4 is also a direct Pax3 target and Sprouty1, which encodes an intracellular inhibitor of fibroblast growth factor (FGF) signaling, is under Pax3 control. Orchestration of FGF signaling, through Fgfr4/Sprouty1, modulates the entry of cells into the myogenic program, thus controling the balance between stem cell self-renewal and tissue differentiation. This and other aspects of Pax3/7 function in regulating the behavior of skeletal muscle stem cells are discussed.

本文言語English
ページ(範囲)307-315
ページ数9
ジャーナルCold Spring Harbor Symposia on Quantitative Biology
73
DOI
出版ステータスPublished - 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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