Regulators of small GTPases.

Y. Takai, K. Kaibuchi, A. Kikuchi, T. Sasaki, H. Shirataki

研究成果: Review article査読

27 被引用数 (Scopus)

抄録

Small GTPases are converted from the GDP-bound inactive form to the GTP-bound active form by a GDP/GTP exchange reaction which is regulated by GDP/GTP exchange proteins (GEPs). We have found both stimulatory and inhibitory GEPs, which we have named GDP dissociation stimulators (GDSs) and GDP dissociation inhibitors (GDIs) respectively. We have isolated Smg GDS, Rho GDI and Rab GDI, cloned them, and determined their primary structures. These GEPs are active on a group of small GTPases: Smg GDS on at least K-Ras, Rap1/Smg21, Rho and Rac; Rho GDI on at least Rho, Rac and Cdc42; Rab GDI on most of the Rab family members. These GEPs have an additional function, regulating the translocation of their substrate small GTPases between the membrane and the cytosol. The GEPs interact only with the post-translationally modified form of their substrate small GTPases.

本文言語English
ページ(範囲)128-138; discussion 138-146
ジャーナルCiba Foundation symposium
176
出版ステータスPublished - 1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

フィンガープリント

「Regulators of small GTPases.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル