Regulatory role of B-1 B cells in chronic colitis

Yasuyo Shimomura, Emiko Mizoguchi, Ken Sugimoto, Ryoko Kibe, Yoshimi Benno, Atsushi Mizoguchi, Atul K. Bhan

研究成果: Article

82 引用 (Scopus)

抜粋

According to the 'hygiene hypothesis', enhanced microbial exposure due to early childhood infections leads to a reduction of Th 2-mediated allergic diseases and inflammatory bowel disease. To begin to elucidate the mechanisms underlying this hypothesis, we studied development of Th2-mediated colitis of the TCRα knockout (KO) mouse in both a specific pathogen-free (SPF) facility and a conventional (CV) facility. After more than five generations in each facility, TCRα KO mice kept in the CV facility developed dramatically less colitis than mice that were kept in the SPF facility. Surprisingly, the suppression of colitis in the CV facility correlated with a significant increase in natural IgM production by B-1 B cells. In contrast, B cell-deficient TCRα double-knockout (αμ DKO) mice maintained in the CV facility continued to develop severe colitis, strongly suggesting that B-1 B cells contributed to the suppression of colitis. Indeed, the adoptive transfer of B-1 B cells isolated from the peritoneal cavity of TCRα KO mice (SPF) into αμ DKO mice (CV) suppressed the development of colitis in the recipient mice. We conclude that B-1 cells play a regulatory role in Th 2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora.

元の言語English
ページ(範囲)729-737
ページ数9
ジャーナルInternational Immunology
20
発行部数6
DOI
出版物ステータスPublished - 01-06-2008
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

フィンガープリント Regulatory role of B-1 B cells in chronic colitis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Shimomura, Y., Mizoguchi, E., Sugimoto, K., Kibe, R., Benno, Y., Mizoguchi, A., & Bhan, A. K. (2008). Regulatory role of B-1 B cells in chronic colitis. International Immunology, 20(6), 729-737. https://doi.org/10.1093/intimm/dxn031