Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study

Yoshimitsu Niwa, Hiroshi Yatsuya, Koji Tamakoshi, Kazuko Nishio, Takaaki Kondo, Yingsong Lin, Sadao Suzuki, Kenji Wakai, Shinkan Tokudome, Akio Yamamoto, Nobuyuki Hamajima, Hideaki Toyoshima, Akiko Tamakoshi

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. Results: Compared to women with BMI of 18.5-24.9 kg/m 2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of ≥30 kg/m 2. A test for trend revealed that this finding was statistically significant (P = 0.014). Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

本文言語English
ページ(範囲)452-458
ページ数7
ジャーナルJournal of Obstetrics and Gynaecology Research
31
5
DOI
出版ステータスPublished - 01-10-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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