Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors

Yoshihito Nakagawa, Yukihiro Akao, Kohei Taniguchi, Akemi Kamatani, Tomomitsu Tahara, Toshiaki Kamano, Naoko Nakano, Naruomi Komura, Hirokazu Ikuno, Takafumi Ohmori, Yasutaka Jodai, Masahiro Miyata, Mistuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya, Ichiro Hirata

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

本文言語English
ページ(範囲)1526-1543
ページ数18
ジャーナルInternational journal of molecular sciences
16
1
DOI
出版ステータスPublished - 09-01-2015

All Science Journal Classification (ASJC) codes

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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