Relationship between retinal layer thickness and focal macular electroretinogram components after epiretinal membrane surgery

Nobuaki Hibi, Shinji Ueno, Yasuki Ito, Chang Hua Piao, Mineo Kondo, Hiroko Terasaki

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Purpose. To study the effect of epiretinal membrane (ERM) removal on the function and structure of the retina, and to determine whether the functional changes were correlated with the changes in the thickness of different retinal layers. Methods. Focal macular electroretinography (FMERG) and spectral-domain optical coherence tomography (SD-OCT) were performed on 17 eyes of 15 patients before and after ERM surgery. The parafoveal retina was divided into an inner layer, a middle layer, and an outer layer in the OCT images. The thickness of each layer was measured before and after the ERM surgery. The a-wave, b-wave, and oscillatory potentials (OPs) of the FMERGs were analyzed before and after the ERM surgery. Results. The thickness of the inner and middle retinal layers was significantly reduced after surgery (by 39% and 23%, respectively). The mean amplitudes of the b-waves and OPs at 6 months postoperatively were significantly larger than those recorded preoperatively (by 21% and 61%, respectively). The ratios of the pre- to postoperative b-wave and OP amplitudes were correlated with the thickness reduction of the middle retinal layer (b-wave, r = -0.51, P < 0.05; OPs, r = -0.82, P < 0.01). Conclusions. The significant correlations between the reduction in the thickness of the middle retinal layer and increase in the amplitude of the b-waves and OPs suggest that the improvement of macular function after ERM peeling is due to the decrease in the thickness of the middle retinal layer.

本文言語English
ページ(範囲)7207-7214
ページ数8
ジャーナルInvestigative Ophthalmology and Visual Science
54
12
DOI
出版ステータスPublished - 08-10-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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