Relationship between serum carotenoids and hyperglycemia: A population-based cross-sectional study

Koji Suzuki, Yoshinori Ito, Sayuri Nakamura, Junichi Ochiai, Kunio Aoki

研究成果: Article

40 引用 (Scopus)

抄録

The present study investigated the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits. Subjects with a history of diabetes mellitus (DM group, n=133) or with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n=151) were recruited from among inhabitants of a rural area in Hokkaido, Japan. Intake frequencies of vegetables and fruits were assessed using a questionnaire administered by public health nurses. Serum levels of carotenoids and retinol were measured using high-performance liquid chromatography. The relationships between high HbA1c or DM and both serum carotenoids and intake frequencies of vegetables and fruits were analyzed using logistic regression modeling for a case-control study; each case (High HbA1c or DM) was matched to two controls (healthy subjects without any history of disease) matched for sex and age (within 3 years). The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% CI: 0.79-1.84). No significant relationships were observed between high HbA1c and intake frequencies of other vegetables and fruits. The ORs on high serum levels of α- and β-carotenes, lycopene, β-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia.

元の言語English
ページ(範囲)357-366
ページ数10
ジャーナルJournal of Epidemiology
12
発行部数5
DOI
出版物ステータスPublished - 01-01-2002

Fingerprint

Carotenoids
Hyperglycemia
Vegetables
Fruit
Cross-Sectional Studies
Serum
Population
Odds Ratio
Public Health Nurses
Lutein
Cucurbita
Daucus carota
Vitamin A
Case-Control Studies
Diabetes Mellitus
Healthy Volunteers
Japan
Hemoglobins
Logistic Models
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Suzuki, Koji ; Ito, Yoshinori ; Nakamura, Sayuri ; Ochiai, Junichi ; Aoki, Kunio. / Relationship between serum carotenoids and hyperglycemia : A population-based cross-sectional study. :: Journal of Epidemiology. 2002 ; 巻 12, 番号 5. pp. 357-366.
@article{3e7ade2e3c6643ba83388632e4c12f61,
title = "Relationship between serum carotenoids and hyperglycemia: A population-based cross-sectional study",
abstract = "The present study investigated the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits. Subjects with a history of diabetes mellitus (DM group, n=133) or with hyperglycemia diagnosed using a 5.6{\%} cutoff value for hemoglobin A1c (High HbA1c group, n=151) were recruited from among inhabitants of a rural area in Hokkaido, Japan. Intake frequencies of vegetables and fruits were assessed using a questionnaire administered by public health nurses. Serum levels of carotenoids and retinol were measured using high-performance liquid chromatography. The relationships between high HbA1c or DM and both serum carotenoids and intake frequencies of vegetables and fruits were analyzed using logistic regression modeling for a case-control study; each case (High HbA1c or DM) was matched to two controls (healthy subjects without any history of disease) matched for sex and age (within 3 years). The odds ratio (OR) for high HbA1c was 0.49 (95{\%} confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95{\%} CI: 0.79-1.84). No significant relationships were observed between high HbA1c and intake frequencies of other vegetables and fruits. The ORs on high serum levels of α- and β-carotenes, lycopene, β-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia.",
author = "Koji Suzuki and Yoshinori Ito and Sayuri Nakamura and Junichi Ochiai and Kunio Aoki",
year = "2002",
month = "1",
day = "1",
doi = "10.2188/jea.12.357",
language = "English",
volume = "12",
pages = "357--366",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "5",

}

Relationship between serum carotenoids and hyperglycemia : A population-based cross-sectional study. / Suzuki, Koji; Ito, Yoshinori; Nakamura, Sayuri; Ochiai, Junichi; Aoki, Kunio.

:: Journal of Epidemiology, 巻 12, 番号 5, 01.01.2002, p. 357-366.

研究成果: Article

TY - JOUR

T1 - Relationship between serum carotenoids and hyperglycemia

T2 - A population-based cross-sectional study

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Nakamura, Sayuri

AU - Ochiai, Junichi

AU - Aoki, Kunio

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The present study investigated the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits. Subjects with a history of diabetes mellitus (DM group, n=133) or with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n=151) were recruited from among inhabitants of a rural area in Hokkaido, Japan. Intake frequencies of vegetables and fruits were assessed using a questionnaire administered by public health nurses. Serum levels of carotenoids and retinol were measured using high-performance liquid chromatography. The relationships between high HbA1c or DM and both serum carotenoids and intake frequencies of vegetables and fruits were analyzed using logistic regression modeling for a case-control study; each case (High HbA1c or DM) was matched to two controls (healthy subjects without any history of disease) matched for sex and age (within 3 years). The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% CI: 0.79-1.84). No significant relationships were observed between high HbA1c and intake frequencies of other vegetables and fruits. The ORs on high serum levels of α- and β-carotenes, lycopene, β-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia.

AB - The present study investigated the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits. Subjects with a history of diabetes mellitus (DM group, n=133) or with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n=151) were recruited from among inhabitants of a rural area in Hokkaido, Japan. Intake frequencies of vegetables and fruits were assessed using a questionnaire administered by public health nurses. Serum levels of carotenoids and retinol were measured using high-performance liquid chromatography. The relationships between high HbA1c or DM and both serum carotenoids and intake frequencies of vegetables and fruits were analyzed using logistic regression modeling for a case-control study; each case (High HbA1c or DM) was matched to two controls (healthy subjects without any history of disease) matched for sex and age (within 3 years). The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% CI: 0.79-1.84). No significant relationships were observed between high HbA1c and intake frequencies of other vegetables and fruits. The ORs on high serum levels of α- and β-carotenes, lycopene, β-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia.

UR - http://www.scopus.com/inward/record.url?scp=0036726402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036726402&partnerID=8YFLogxK

U2 - 10.2188/jea.12.357

DO - 10.2188/jea.12.357

M3 - Article

C2 - 12395879

AN - SCOPUS:0036726402

VL - 12

SP - 357

EP - 366

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 5

ER -