Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Lung Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study

Truong Minh Pham, Yoshihisa Fujino, Masahiko Ando, Koji Suzuki, Kei Nakachi, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Akiko Tamakoshi, Takesumi Yoshimura, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu HoshiyamaNaohito Tanabe, Koji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio

研究成果: Article

4 引用 (Scopus)

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The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumorfree tissues. In the present study, we investigated the association between serum SOD activity and the risk of lung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study, with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lung cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second, third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI: 0.30-1.07), 1.16 (0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORs of 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, we found no significant association between serum SOD level and the risk of deaths from lung cancer in the present study.

元の言語English
ページ(範囲)75-80
ページ数6
ジャーナルAsian Pacific Journal of Cancer Prevention
10
発行部数SUPPL.1
出版物ステータスPublished - 12-2009

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

これを引用

Pham, T. M., Fujino, Y., Ando, M., Suzuki, K., Nakachi, K., Ito, Y., Watanabe, Y., Inaba, Y., Tajima, K., Tamakoshi, A., Yoshimura, T., Mori, M., Sakauchi, F., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Kurosawa, M., ... Shio, H. (2009). Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Lung Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study. Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 75-80.