Relationship between spleen size and exercise tolerance in advanced heart failure patients with a left ventricular assist device

Hiroaki Hiraiwa, Takahiro Okumura, Akinori Sawamura, Takashi Araki, Takashi Mizutani, Shingo Kazama, Yuki Kimura, Naoki Shibata, Hideo Oishi, Tasuku Kuwayama, Toru Kondo, Kenji Furusawa, Ryota Morimoto, Takuji Adachi, Sumio Yamada, Masato Mutsuga, Akihiko Usui, Toyoaki Murohara

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

Objective: Spleen volume increases in patients with advanced heart failure (HF) after left ventricular assist device (LVAD) implantation. However, the relationship between spleen volume and exercise tolerance (peak oxygen consumption [VO2]) in these patients remains unknown. In this exploratory study, we enrolled 27 patients with HF using a LVAD (median age: 46 years). Patients underwent blood testing, echocardiography, right heart catheterization, computed tomography (CT), and cardiopulmonary exercise testing. Spleen size was measured using CT volumetry, and the correlations/causal relationships of factors affecting peak VO2 were identified using structural equation modeling. Results: The median spleen volume was 190.0 mL, and peak VO2 was 13.2 mL/kg/min. The factors affecting peak VO2 were peak heart rate (HR; β = 0.402, P =.015), pulmonary capillary wedge pressure (PCWP; β = − 0.698, P =.014), right ventricular stroke work index (β = 0.533, P =.001), blood hemoglobin concentration (β = 0.359, P =.007), and spleen volume (β = 0.215, P =.041). Spleen volume correlated with peak HR, PCWP, and hemoglobin concentration, reflecting sympathetic activity, cardiac preload, and oxygen-carrying capacity, respectively, and was thus related to peak VO2. These results suggest an association between spleen volume and exercise tolerance in advanced HF.

本文言語英語
論文番号40
ジャーナルBMC Research Notes
15
1
DOI
出版ステータス出版済み - 12-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学一般

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