Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

Le Hoa Nguyen, Shingo Kakeda, Asuka Katsuki, Koichiro Sugimoto, Yuka Otsuka, Issei Ueda, Ryohei Igata, Keita Watanabe, Taro Kishi, Nakao Iwata, Yukunori Korogi, Reiji Yoshimura

研究成果: Article

3 引用 (Scopus)

抄録

Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-naïve MDD patients. A total of 38 first-episode drug-naïve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-naïve MDD patients.

元の言語English
ページ(範囲)785-794
ページ数10
ジャーナルEuropean Archives of Psychiatry and Clinical Neuroscience
269
発行部数7
DOI
出版物ステータスPublished - 01-10-2019

Fingerprint

Major Depressive Disorder
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Brain
Genotype
Genes
Hippocampus
Healthy Volunteers
Therapeutics
Hypochondriasis
Pharmaceutical Preparations
Genome-Wide Association Study
Atrophy
Serum

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

これを引用

Nguyen, Le Hoa ; Kakeda, Shingo ; Katsuki, Asuka ; Sugimoto, Koichiro ; Otsuka, Yuka ; Ueda, Issei ; Igata, Ryohei ; Watanabe, Keita ; Kishi, Taro ; Iwata, Nakao ; Korogi, Yukunori ; Yoshimura, Reiji. / Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. :: European Archives of Psychiatry and Clinical Neuroscience. 2019 ; 巻 269, 番号 7. pp. 785-794.
@article{35f6c2dd975f4d48b82070364cf07d47,
title = "Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-na{\"i}ve patients with first-episode major depressive disorder",
abstract = "Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-na{\"i}ve MDD patients. A total of 38 first-episode drug-na{\"i}ve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-na{\"i}ve MDD patients.",
author = "Nguyen, {Le Hoa} and Shingo Kakeda and Asuka Katsuki and Koichiro Sugimoto and Yuka Otsuka and Issei Ueda and Ryohei Igata and Keita Watanabe and Taro Kishi and Nakao Iwata and Yukunori Korogi and Reiji Yoshimura",
year = "2019",
month = "10",
day = "1",
doi = "10.1007/s00406-018-0953-8",
language = "English",
volume = "269",
pages = "785--794",
journal = "Archiv fur Psychiatrie und Nervenkrankheiten",
issn = "0003-9373",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

Nguyen, LH, Kakeda, S, Katsuki, A, Sugimoto, K, Otsuka, Y, Ueda, I, Igata, R, Watanabe, K, Kishi, T, Iwata, N, Korogi, Y & Yoshimura, R 2019, 'Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder', European Archives of Psychiatry and Clinical Neuroscience, 巻. 269, 番号 7, pp. 785-794. https://doi.org/10.1007/s00406-018-0953-8

Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. / Nguyen, Le Hoa; Kakeda, Shingo; Katsuki, Asuka; Sugimoto, Koichiro; Otsuka, Yuka; Ueda, Issei; Igata, Ryohei; Watanabe, Keita; Kishi, Taro; Iwata, Nakao; Korogi, Yukunori; Yoshimura, Reiji.

:: European Archives of Psychiatry and Clinical Neuroscience, 巻 269, 番号 7, 01.10.2019, p. 785-794.

研究成果: Article

TY - JOUR

T1 - Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

AU - Nguyen, Le Hoa

AU - Kakeda, Shingo

AU - Katsuki, Asuka

AU - Sugimoto, Koichiro

AU - Otsuka, Yuka

AU - Ueda, Issei

AU - Igata, Ryohei

AU - Watanabe, Keita

AU - Kishi, Taro

AU - Iwata, Nakao

AU - Korogi, Yukunori

AU - Yoshimura, Reiji

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-naïve MDD patients. A total of 38 first-episode drug-naïve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-naïve MDD patients.

AB - Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-naïve MDD patients. A total of 38 first-episode drug-naïve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging. Blood samples were collected from all the participants for serum VEGF assays and VEGF-related SNPs genotyping. Genotype–diagnosis interactions related to whole-brain cortical thickness and hippocampal subfield volumes were evaluated for the four SNPs. The results revealed a genotype–diagnosis interaction only for rs6921438 (i.e., the MDD patients and HS with the G/G genotype versus the MDD patients and HS with A-carrier genotype) in the subiculum of the left hippocampus (p < 0.05), and not the other SNPs. There was a volume reduction in the left subiculum of G/G genotype patients compared with the other groups. The “hypochondriasis” scores of the HAMD-17 scale were significantly higher in the G/G genotype patients than the A-carrier genotype patients. The association was observed between VEGF-related SNP rs6921438 and subiculum atrophy in first-episode drug-naïve MDD patients.

UR - http://www.scopus.com/inward/record.url?scp=85056087831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056087831&partnerID=8YFLogxK

U2 - 10.1007/s00406-018-0953-8

DO - 10.1007/s00406-018-0953-8

M3 - Article

C2 - 30406404

AN - SCOPUS:85056087831

VL - 269

SP - 785

EP - 794

JO - Archiv fur Psychiatrie und Nervenkrankheiten

JF - Archiv fur Psychiatrie und Nervenkrankheiten

SN - 0003-9373

IS - 7

ER -