TY - JOUR
T1 - Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population
AU - Yamada, Youhei
AU - Nakamura, Haruki
AU - Tsujiguchi, Hiromasa
AU - Hara, Akinori
AU - Miyagi, Sakae
AU - Kannon, Takayuki
AU - Sato, Takehiro
AU - Hosomichi, Kazuyoshi
AU - Nguyen, Thao Thi Thu
AU - Kambayashi, Yasuhiro
AU - Shimizu, Yukari
AU - Pham, Kim Oanh
AU - Suzuki, Keita
AU - Suzuki, Fumihiko
AU - Kasahara, Tomoko
AU - Tsuboi, Hirohito
AU - Tajima, Atsushi
AU - Nakamura, Hiroyuki
N1 - Publisher Copyright:
Copyright: © 2021 Yamada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/8
Y1 - 2021/8
N2 - A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.
AB - A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.
UR - https://www.scopus.com/pages/publications/85111973352
UR - https://www.scopus.com/pages/publications/85111973352#tab=citedBy
U2 - 10.1371/journal.pone.0255444
DO - 10.1371/journal.pone.0255444
M3 - Article
C2 - 34347822
AN - SCOPUS:85111973352
SN - 1932-6203
VL - 16
JO - PloS one
JF - PloS one
IS - 8 August
M1 - e0255444
ER -
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