TY - JOUR
T1 - Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians
AU - Iida, Aritoshi
AU - Takahashi, Atsushi
AU - Deng, Min
AU - Zhang, Yun
AU - Wang, Jing
AU - Atsuta, Naoki
AU - Tanaka, Fumiaki
AU - Kamei, Tetsumasa
AU - Sano, Motoki
AU - Oshima, Shuichi
AU - Tokuda, Torao
AU - Morita, Mitsuya
AU - Akimoto, Chizuru
AU - Nakajima, Masahiro
AU - Kubo, Michiaki
AU - Kamatani, Naoyuki
AU - Nakano, Imaharu
AU - Sobue, Gen
AU - Nakamura, Yusuke
AU - Fan, Dongsheng
AU - Ikegawa, Shiro
PY - 2011/4
Y1 - 2011/4
N2 - We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.
AB - We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.
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U2 - 10.1016/j.neurobiolaging.2010.12.011
DO - 10.1016/j.neurobiolaging.2010.12.011
M3 - Article
C2 - 21295378
AN - SCOPUS:79953033142
SN - 0197-4580
VL - 32
SP - 757.e13-757.e14
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4
ER -