Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians

Aritoshi Iida, Atsushi Takahashi, Min Deng, Yun Zhang, Jing Wang, Naoki Atsuta, Fumiaki Tanaka, Tetsumasa Kamei, Motoki Sano, Shuichi Oshima, Torao Tokuda, Mitsuya Morita, Chizuru Akimoto, Masahiro Nakajima, Michiaki Kubo, Naoyuki Kamatani, Imaharu Nakano, Gen Sobue, Yusuke Nakamura, Dongsheng FanShiro Ikegawa

研究成果: Article査読

23 被引用数 (Scopus)

抄録

We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.

本文言語English
ページ(範囲)757.e13-757.e14
ジャーナルNeurobiology of Aging
32
4
DOI
出版ステータスPublished - 04-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 加齢科学
  • 発生生物学
  • 臨床神経学
  • 老年医学

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