Reprint of: Chromogranin A: A new proposal for trafficking, processing and induction of granule biogenesis

Hisatsugu Koshimizu, Taeyoon Kim, Niamh X. Cawley, Y. Peng Loh

研究成果: Article

5 引用 (Scopus)

抄録

Chromogranin A (CgA), a member of the granin family serves several important cell biological roles in (neuro)endocrine cells which are summarized in this review. CgA is a "prohormone" that is synthesized at the rough endoplasmic reticulum and transported into the cisternae of this organelle via its signal peptide. It is then trafficked to the Golgi complex and then to the trans-Golgi network (TGN) where CgA aggregates at low pH in the presence of calcium. The CgA aggregates provide the physical driving force to induce budding of the TGN membrane resulting in dense core granule (DCG) formation. Within the granule, a small amount of the CgA is processed to bioactive peptides, including a predicted C-terminal peptide, serpinin. Upon stimulation, DCGs undergo exocytosis and CgA and its derived peptides are released. Serpinin, acting extracellularly is able to signal the increase in transcription of a serine protease inhibitor, protease nexin-1 (PN-1) that protects DCG proteins against degradation in the Golgi complex, which then enhances DCG biogenesis to replenish those that were released. Thus CgA and its derived peptide, serpinin, plays a significant role in granule formation and regulation of granule biogenesis, respectively, in (neuro) endocrine cells.

元の言語English
ページ(範囲)95-101
ページ数7
ジャーナルRegulatory Peptides
165
発行部数1
DOI
出版物ステータスPublished - 30-11-2010

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Chromogranin A
Processing
trans-Golgi Network
Peptides
Endocrine Cells
Golgi Apparatus
Protease Nexins
Cells
Chromogranins
Serine Proteinase Inhibitors
Rough Endoplasmic Reticulum
Exocytosis
Transcription
Protein Sorting Signals
Organelles
Proteolysis
Calcium
Membranes
Degradation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

これを引用

Koshimizu, Hisatsugu ; Kim, Taeyoon ; Cawley, Niamh X. ; Loh, Y. Peng. / Reprint of : Chromogranin A: A new proposal for trafficking, processing and induction of granule biogenesis. :: Regulatory Peptides. 2010 ; 巻 165, 番号 1. pp. 95-101.
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Reprint of : Chromogranin A: A new proposal for trafficking, processing and induction of granule biogenesis. / Koshimizu, Hisatsugu; Kim, Taeyoon; Cawley, Niamh X.; Loh, Y. Peng.

:: Regulatory Peptides, 巻 165, 番号 1, 30.11.2010, p. 95-101.

研究成果: Article

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