Restenosis and stent fracture following sirolimus-eluting stent (SES) implantation - A serial quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) study

Masanori Okumura, Yukio Ozaki, Junichi Ishii, Shino Kan, Hiroyuki Naruse, Shigeru Matsui, Makoto Ishikawa, Kousuke Hattori, Tomoko Gochi, Tadashi Nakano, Akira Yamada, Shigeru Kato, Sadako Motoyama, Masayoshi Sarai, Yasushi Takagi, Tevfik F. Ismail, Masanori Nomura, Hitoshi Hishida

研究成果: Article

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Background: Restenosis still occurs, even with the sirolimus-eluting stent (SES), and the precise mechanisms and the impact of stent fracture on restensosis have not yet been elucidated. Methods and Results: Intravascular ultrasound (IVUS)-guided SES implantation was performed in 184 lesions in 151 patients with stable and unstable angina. Serial (pre-, post- and follow-up) quantitative coronary angiography analysis was obtained in 169 lesions in 138 patients (angiographic follow-up rate: 91%) and 12-month clinical follow-up was done in all patients. Restenosis occurred in 13 (7.7%) of 169 lesions. Stent fracture occurred in 4 (2.4%) of 169 lesions at follow-up. Of the 13 restenotic lesions, 8 had intimal hyperplasia, 4 had stent fracture, and 1 had late stent thrombosis at 7 months. Although multivariate logistic regression analysis revealed that minimal lumen area (min-LA) post (p=0.027), total stent length (p=0.003) and diabetes (p=0.032) were significant independent predictors of restenosis, univariate analysis showed that stent fracture was more common in the restenosis than in the non-restenosis groups (p=0.001). Conclusions: Although min-LA post by IVUS, total stent length by QCA and diabetes are independent predictors for angiographic restenosis, stent fracture occurred in 4 lesions (2.4%) and all of them resulted in restenosis (31% of the restenosis). The impact of stent fracture and its potential role in the development of restenosis deserves further study.

元の言語English
ページ(範囲)1669-1677
ページ数9
ジャーナルCirculation Journal
71
発行部数11
DOI
出版物ステータスPublished - 17-12-2007

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Okumura, M., Ozaki, Y., Ishii, J., Kan, S., Naruse, H., Matsui, S., Ishikawa, M., Hattori, K., Gochi, T., Nakano, T., Yamada, A., Kato, S., Motoyama, S., Sarai, M., Takagi, Y., Ismail, T. F., Nomura, M., & Hishida, H. (2007). Restenosis and stent fracture following sirolimus-eluting stent (SES) implantation - A serial quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) study. Circulation Journal, 71(11), 1669-1677. https://doi.org/10.1253/circj.71.1669