TY - JOUR
T1 - Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression
AU - Noman, Abu Shadat Mohammod
AU - Koide, Naoki
AU - Iftakhar-E-Khuda, Imtiaz
AU - Dagvadorj, Jargalsaikhan
AU - Tumurkhuu, Gantsetseg
AU - Naiki, Yoshikazu
AU - Komatsu, Takayuki
AU - Yoshida, Tomoaki
AU - Yokochi, Takashi
N1 - Funding Information:
This work was supported, in part, by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan . We are grateful to K. Takahashi and A. Morikawa for the technical assistance.
PY - 2010/7
Y1 - 2010/7
N2 - The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) in receptor activator of NF-κB ligand (RANKL)-induced osteoclast formation was examined in mouse RAW 264.7 macrophage-like cells. The expression of RIZ1 was significantly augmented by RANKL-treated cells. Silencing of RIZ1 with the siRNA significantly reduced the appearance of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells as osteoclasts in RANKL-treated cells. The expression of nuclear factor of activated T cell 1 (NFATc1) as the terminal transcription factor of osteoclast formation was prevented by RIZ1 siRNA. It was suggested that that RIZ1 might participate in RANKL-induced osteoclast formation through the regulation of NFATc1 expression.
AB - The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) in receptor activator of NF-κB ligand (RANKL)-induced osteoclast formation was examined in mouse RAW 264.7 macrophage-like cells. The expression of RIZ1 was significantly augmented by RANKL-treated cells. Silencing of RIZ1 with the siRNA significantly reduced the appearance of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells as osteoclasts in RANKL-treated cells. The expression of nuclear factor of activated T cell 1 (NFATc1) as the terminal transcription factor of osteoclast formation was prevented by RIZ1 siRNA. It was suggested that that RIZ1 might participate in RANKL-induced osteoclast formation through the regulation of NFATc1 expression.
UR - https://www.scopus.com/pages/publications/77953695770
UR - https://www.scopus.com/pages/publications/77953695770#tab=citedBy
U2 - 10.1016/j.imlet.2010.04.006
DO - 10.1016/j.imlet.2010.04.006
M3 - Article
C2 - 20417662
AN - SCOPUS:77953695770
SN - 0165-2478
VL - 131
SP - 166
EP - 169
JO - Immunology Letters
JF - Immunology Letters
IS - 2
ER -