Reverse genetics system for human rotaviruses

Satoshi Komoto, Saori Fukuda, Takayuki Murata, Koki Taniguchi

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

A reverse genetics technology is an incredibly useful technique both for a proper understanding of different aspects of virus biology and for the generation of complementary DNA (cDNA)-derived infectious viruses, which can act as safe and effective vaccines and viral vectors. Rotaviruses (RVAs), especially human RVAs (HuRVAs), had been very refractory to this technology until very recently. Here, we describe the historical background of the development of a long-awaited HuRVA reverse genetics system, culminating in the generation of replicative HuRVAs entirely from cloned cDNAs.

本文言語English
ページ(範囲)401-406
ページ数6
ジャーナルMICROBIOLOGY and IMMUNOLOGY
64
6
DOI
出版ステータスPublished - 01-06-2020

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 免疫学
  • ウイルス学

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