Reversible cerebral vasoconstriction syndrome triggered by tacrolimus mimicked neuropsychiatric involvement in systemic lupus erythematosus

Jun Inamo, Jun Kikuchi, Katsuya Suzuki, Yuko Kaneko, Hidekata Yasuoka, Hirokazu Fujiwara, Kunihiro Yamaoka, Tsutomu Takeuchi

研究成果: Article査読

抄録

A 38-year-old woman, who was diagnosed with systemic lupus erythematosus (SLE) and treated with tacrolimus and prednisolone, developed severe headache suddenly. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) showed multiple constrictive lesions of right middle cerebral arteries and subarachnoid haemorrhage. The level of interleukin (IL)-6 in cerebrospinal fluid (CSF) was elevated to 301 pg/ml. Tacrolimus was discontinued, and then her symptoms started to improve on day 2. At day 6, MRI findings and IL-6 level in CSF also dramatically improved. Our case demonstrated that tacrolimus could trigger reversible cerebral vasoconstriction syndrome (RCVS) in SLE patients, even though the level of tacrolimus was kept in treatment level stably.

本文言語English
ページ(範囲)119-123
ページ数5
ジャーナルModern Rheumatology Case Reports
3
2
DOI
出版ステータスPublished - 03-07-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • リウマチ学

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