### 抄録

Background: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities. Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m^{2} and serum creatinine was assayed in different laboratories. Study Design: Diagnostic test study using a prospective cross-sectional design. New equations were developed in 413 participants and validated in 350 participants. All samples were assayed in a central laboratory. Setting & Participants: Hospitalized Japanese patients in 80 medical centers. Patients had not participated in the previous study. Reference Test: Measured GFR (mGFR) computed from inulin clearance. Index Test: Estimated GFR (eGFR) by using the modified isotope dilution mass spectrometry (IDMS)-traceable 4-variable Modification of Diet in Renal Disease (MDRD) Study equation using the previous Japanese Society of Nephrology Chronic Kidney Disease Initiative (JSN-CKDI) coefficient of 0.741 (equation 1), the previous JSN-CKDI equation (equation 2), and new equations derived in the development data set: modified MDRD Study using a new Japanese coefficient (equation 3), and a 3-variable Japanese equation (equation 4). Measurements: Performance of equations was assessed by means of bias (eGFR-mGFR), accuracy (percentage of estimates within 15% or 30% of mGFR), root mean squared error, and correlation coefficient. Results: In the development data set, the new Japanese coefficient was 0.808 (95% confidence interval, 0.728 to 0.829) for the IDMS-MDRD Study equation (equation 3), and the 3-variable Japanese equation (equation 4) was eGFR (mL/min/1.73 m^{2}) = 194 × Serum creatinine^{-1.094} × Age^{-0.287} × 0.739 (if female). In the validation data set, bias was -1.3 ± 19.4 versus -5.9 ± 19.0 mL/min/1.73 m^{2} (P = 0.002), and accuracy within 30% of mGFR was 73% versus 72% (P = 0.6) for equation 3 versus equation 1 and-2.1±19.0 versus-7.9±18.7 mL/min/1.73m^{2} (P<0.001) and 75% versus 73% (P= 0.06) for equation 4 versus equation 2 (P = 0.06), respectively. Limitation: Most study participants had chronic kidney disease, and some may have had changing GFRs. Conclusion: The new Japanese coefficient for the modified IDMS-MDRD Study equation and the new Japanese equation are more accurate for the Japanese population than the previously reported equations. Am J Kidney Dis 53:982-992.

元の言語 | English |
---|---|

ページ（範囲） | 982-992 |

ページ数 | 11 |

ジャーナル | American Journal of Kidney Diseases |

巻 | 53 |

発行部数 | 6 |

DOI | |

出版物ステータス | Published - 01-06-2009 |

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### All Science Journal Classification (ASJC) codes

- Nephrology

### これを引用

*American Journal of Kidney Diseases*,

*53*(6), 982-992. https://doi.org/10.1053/j.ajkd.2008.12.034

}

*American Journal of Kidney Diseases*, 巻. 53, 番号 6, pp. 982-992. https://doi.org/10.1053/j.ajkd.2008.12.034

**Revised Equations for Estimated GFR From Serum Creatinine in Japan.** / Japanese equation for estimated GFR.

研究成果: Article

TY - JOUR

T1 - Revised Equations for Estimated GFR From Serum Creatinine in Japan

AU - Japanese equation for estimated GFR

AU - Matsuo, Seiichi

AU - Imai, Enyu

AU - Horio, Masaru

AU - Yasuda, Yoshinari

AU - Tomita, Kimio

AU - Nitta, Kosaku

AU - Yamagata, Kunihiro

AU - Tomino, Yasuhiko

AU - Yokoyama, Hitoshi

AU - Hishida, Akira

AU - Kikuchi, Kenjiro

AU - Haneda, Masakazu

AU - Hashimoto, Seiji

AU - Ura, Nobuyuki

AU - Ito, Sadayoshi

AU - Sato, Hiroshi

AU - Watanabe, Tsuyoshi

AU - Ando, Yasuhiro

AU - Kusano, Eiji

AU - Nojima, Yoshihisa

AU - Saitoh, Chie

AU - Shiigai, Tatsuo

AU - Maeda, Yoshitaka

AU - Suzuki, Hiromichi

AU - Watanabe, Yusuke

AU - Mitarai, Tetsuya

AU - Hasegawa, Hajime

AU - Fujita, Toshiro

AU - Hosoya, Tatsuo

AU - Matsumoto, Koichi

AU - Fujita, Takayuki

AU - Sanaka, Tsutomu

AU - Kanda, Eiichiro

AU - Sasaki, Sei

AU - Nakano, Toshiyuki

AU - Akizawa, Tadao

AU - Honda, Hirokazu

AU - Inoue, Yoshihiko

AU - Yoshimura, Ashio

AU - Fukunaga, Megumu

AU - Tsuji, Hiroshi

AU - Ohashi, Yasushi

AU - Nakajima, Hideaki

AU - Uchida, Shunya

AU - Yamada, Akira

AU - Umemura, Satoshi

AU - Yanagi, Mai

AU - Yamakawa, Hiro

AU - Kimura, Kenjiro

AU - Nishi, Shinichi

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Background: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities. Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories. Study Design: Diagnostic test study using a prospective cross-sectional design. New equations were developed in 413 participants and validated in 350 participants. All samples were assayed in a central laboratory. Setting & Participants: Hospitalized Japanese patients in 80 medical centers. Patients had not participated in the previous study. Reference Test: Measured GFR (mGFR) computed from inulin clearance. Index Test: Estimated GFR (eGFR) by using the modified isotope dilution mass spectrometry (IDMS)-traceable 4-variable Modification of Diet in Renal Disease (MDRD) Study equation using the previous Japanese Society of Nephrology Chronic Kidney Disease Initiative (JSN-CKDI) coefficient of 0.741 (equation 1), the previous JSN-CKDI equation (equation 2), and new equations derived in the development data set: modified MDRD Study using a new Japanese coefficient (equation 3), and a 3-variable Japanese equation (equation 4). Measurements: Performance of equations was assessed by means of bias (eGFR-mGFR), accuracy (percentage of estimates within 15% or 30% of mGFR), root mean squared error, and correlation coefficient. Results: In the development data set, the new Japanese coefficient was 0.808 (95% confidence interval, 0.728 to 0.829) for the IDMS-MDRD Study equation (equation 3), and the 3-variable Japanese equation (equation 4) was eGFR (mL/min/1.73 m2) = 194 × Serum creatinine-1.094 × Age-0.287 × 0.739 (if female). In the validation data set, bias was -1.3 ± 19.4 versus -5.9 ± 19.0 mL/min/1.73 m2 (P = 0.002), and accuracy within 30% of mGFR was 73% versus 72% (P = 0.6) for equation 3 versus equation 1 and-2.1±19.0 versus-7.9±18.7 mL/min/1.73m2 (P<0.001) and 75% versus 73% (P= 0.06) for equation 4 versus equation 2 (P = 0.06), respectively. Limitation: Most study participants had chronic kidney disease, and some may have had changing GFRs. Conclusion: The new Japanese coefficient for the modified IDMS-MDRD Study equation and the new Japanese equation are more accurate for the Japanese population than the previously reported equations. Am J Kidney Dis 53:982-992.

AB - Background: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities. Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories. Study Design: Diagnostic test study using a prospective cross-sectional design. New equations were developed in 413 participants and validated in 350 participants. All samples were assayed in a central laboratory. Setting & Participants: Hospitalized Japanese patients in 80 medical centers. Patients had not participated in the previous study. Reference Test: Measured GFR (mGFR) computed from inulin clearance. Index Test: Estimated GFR (eGFR) by using the modified isotope dilution mass spectrometry (IDMS)-traceable 4-variable Modification of Diet in Renal Disease (MDRD) Study equation using the previous Japanese Society of Nephrology Chronic Kidney Disease Initiative (JSN-CKDI) coefficient of 0.741 (equation 1), the previous JSN-CKDI equation (equation 2), and new equations derived in the development data set: modified MDRD Study using a new Japanese coefficient (equation 3), and a 3-variable Japanese equation (equation 4). Measurements: Performance of equations was assessed by means of bias (eGFR-mGFR), accuracy (percentage of estimates within 15% or 30% of mGFR), root mean squared error, and correlation coefficient. Results: In the development data set, the new Japanese coefficient was 0.808 (95% confidence interval, 0.728 to 0.829) for the IDMS-MDRD Study equation (equation 3), and the 3-variable Japanese equation (equation 4) was eGFR (mL/min/1.73 m2) = 194 × Serum creatinine-1.094 × Age-0.287 × 0.739 (if female). In the validation data set, bias was -1.3 ± 19.4 versus -5.9 ± 19.0 mL/min/1.73 m2 (P = 0.002), and accuracy within 30% of mGFR was 73% versus 72% (P = 0.6) for equation 3 versus equation 1 and-2.1±19.0 versus-7.9±18.7 mL/min/1.73m2 (P<0.001) and 75% versus 73% (P= 0.06) for equation 4 versus equation 2 (P = 0.06), respectively. Limitation: Most study participants had chronic kidney disease, and some may have had changing GFRs. Conclusion: The new Japanese coefficient for the modified IDMS-MDRD Study equation and the new Japanese equation are more accurate for the Japanese population than the previously reported equations. Am J Kidney Dis 53:982-992.

UR - http://www.scopus.com/inward/record.url?scp=65549111017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549111017&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2008.12.034

DO - 10.1053/j.ajkd.2008.12.034

M3 - Article

C2 - 19339088

AN - SCOPUS:65549111017

VL - 53

SP - 982

EP - 992

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 6

ER -