Les protéines Rho: Leur rôle dans les neurones

Céline Ménager, Kozo Kaibuchi

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

Neurons possess a polarized morphology. In general, each neuron has several dendrites but only one axon. Such morphology is the basis for directionalized rapid signaling, information flowing from the short dendrites to the long axon. The mechanisms involved in the establishment of the neuronal polarity remain largely unknown. However, recently, members of Rho family proteins have been implicated in the regulation of neuronal morphology especially development of neuronal polarity, axon outgrowth and guidance, dendritic tree elaboration and synapse formation. Moreover, the Rho GTPases have been reported to be directly or indirectly involved in some neurological conditions such as X-linked mental retardation as well as Alzheimer's and Parkinson's diseases. These findings demonstrate the importance of Rho GTPases in the development, maintenance and function of the nervous system.

寄稿の翻訳タイトルRho GTpases function in neurons
本文言語French
ページ(範囲)358-363
ページ数6
ジャーナルMedecine/Sciences
19
3
DOI
出版ステータスPublished - 01-03-2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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