Right ventricular endomyocardial biopsy findings in 25 patients with sick sinus syndrome

Akihisa Uemura, Shin Ichiro Morimoto, Shinya Hiramitsu, Masatsugu Ohtsuki, Shigeru Kato, Yasuchika Kato, Atsushi Sugiura, Kenji Miyagishima, Hitoshi Hishida

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)


A variety of myocardial lesions have been demonstrated in atrial muscle in patients with sick sinus syndrome (SSS), but the right ventricular myocardium has not been studied in detail in a large series. Therefore, we performed right ventricular endomyocardial biopsies in 25 patients with SSS (SSS group), and the presence or absence of ventricular myocardial lesions was determined histologically. As a control, biopsies of corresponding sites in 12 normal autopsied hearts were obtained (N group). The mean cardiac myocyte transverse diameter was 14.2 ± 3.6 μm in the SSS group and 11.7 ± 3.1 μm in the N group (P < 0.01). In the SSS group, cardiac myocyte hypertrophy was observed in 20 of 25 subjects (80%), and myocyte size variation was more frequent. Although the difference was not significant, myocyte disorganization, myocytolysis, nuclear deformity, interstitial large mononuclear cell proliferation, and endocardial lesions, which were not seen in the N group, were observed in the SSS group. A variety of myocardial lesions, including cardiac myocyte hypertrophy, are present not only in atrial, but also in ventricular muscle in SSS.

ジャーナルJapanese Heart Journal
出版ステータス出版済み - 2004

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学


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