Ripply2 is essential for precise somite formation during mouse early development

Techuan Chan; Akiko Kondow; Akihiro Hosoya; Keisuke Hitachi; Akira Yukita; Koji Okabayashi; Hiroaki Nakamura; Hidehiro Ozawa; Hiroshi Kiyonari; Tatsuo Michiue; Yuzuru Ito; Makoto Asashima

doi:10.1016/j.febslet.2007.05.017

Ripply2 is essential for precise somite formation during mouse early development

Techuan Chan, Akiko Kondow, Akihiro Hosoya, Keisuke Hitachi, Akira Yukita, Koji Okabayashi, Hiroaki Nakamura, Hidehiro Ozawa, Hiroshi Kiyonari, Tatsuo Michiue, Yuzuru Ito, Makoto Asashima

神経・腫瘍のシグナル解析プロジェクト研究

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

35 被引用数 (Scopus)

抄録

The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.

本文言語	英語
ページ（範囲）	2691-2696
ページ数	6
ジャーナル	FEBS Letters
巻	581
号	14
DOI	https://doi.org/10.1016/j.febslet.2007.05.017
出版ステータス	出版済み - 12-06-2007

All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/j.febslet.2007.05.017

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引用スタイル

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title = "Ripply2 is essential for precise somite formation during mouse early development",

abstract = "The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.",

author = "Techuan Chan and Akiko Kondow and Akihiro Hosoya and Keisuke Hitachi and Akira Yukita and Koji Okabayashi and Hiroaki Nakamura and Hidehiro Ozawa and Hiroshi Kiyonari and Tatsuo Michiue and Yuzuru Ito and Makoto Asashima",

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AU - Chan, Techuan

AU - Kondow, Akiko

AU - Hosoya, Akihiro

AU - Hitachi, Keisuke

AU - Yukita, Akira

AU - Okabayashi, Koji

AU - Nakamura, Hiroaki

AU - Ozawa, Hidehiro

AU - Kiyonari, Hiroshi

AU - Michiue, Tatsuo

AU - Ito, Yuzuru

AU - Asashima, Makoto

PY - 2007/6/12

Y1 - 2007/6/12

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AB - The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.

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Ripply2 is essential for precise somite formation during mouse early development

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All Science Journal Classification (ASJC) codes

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