Risk classification for overall survival by the neutrophil–lymphocyte ratio and the number of metastatic sites in patients treated with pembrolizumab—a multicenter collaborative study in Japan

Taizo Uchimoto, Kazumasa Komura, Wataru Fukuokaya, Takahiro Kimura, Kazuhiro Takahashi, Yusuke Yano, Kazuki Nishimura, Keita Nakamori, Yuya Fujiwara, Tomohisa Matsunaga, Takeshi Tsutsumi, Takuya Tsujino, Ryoichi Maenosono, Yuki Yoshikawa, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Kiyoshi TakaharaTeruo Inamoto, Shin Egawa, Haruhito Azuma

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Pembrolizumab has emerged as the new standard of care in patients with platinum-re-fractory metastatic urothelial carcinoma (mUC), whereas the optimal risk stratification to predict survival outcomes is still controversial. We examined a risk model for overall survival (OS) in mUC treated with pembrolizumab using our multi-institutional dataset (212 patients). The median age was 72 years old. Median OS from the initiation of pembrolizumab treatment was 11.7 months. The objective response rate (ORR) was 26.4%. On multivariate analysis, multiple metastatic sites and an NLR > 3.50 at the initiation of pembrolizumab treatment were identified as independent predictors for OS. We next developed a risk model using those two predictors. Patients without any factors were assigned to the favorable-risk group (26.5%). Patients with either factor and both factors were assigned to the intermediate-risk group (44.3%), and poor-risk group (29.2%), respectively. Kaplan– Meier curves showed clear discrimination of OS among the risk groups (p < 0.001). The ORR in each group was 35.7% in the favorable-risk group, 27.7% in the intermediate-risk group, and 17.7% in the poor-risk group. Given that the model can be concisely determined at the initiation of pembroli-zumab treatment, physicians may be encouraged to consider the risk group for daily practice.

本文言語English
論文番号3554
ジャーナルCancers
13
14
DOI
出版ステータスPublished - 02-07-2021

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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