Risk factors for coronary atherosclerosis in a general Japanese population: The Hisayama study

Yutaka Nakashima, Yutaka Kiyohara, Yasufumi Doi, Michiaki Kubo, Mitsuo Iida, Katsuo Sueishi

研究成果: ジャーナルへの寄稿学術論文査読

17 被引用数 (Scopus)

抄録

To investigate risk factors for coronary atherosclerosis in men and women in the recent general Japanese population, we examined coronary arteries obtained from subjects autopsied in the Hisayama cohort study (autopsy rate: 78.7%). The subjects were over 40 years of age and consisted of 125 men and 108 women. They underwent an antemortem medical examination in 1988 and were subject to autopsy at death during an 8-year follow-up period. Atherosclerosis was globally assessed by examining 14 specimens taken from wide areas of epicardial coronary arteries and classified into 6 grades. The frequency of more severe grades of coronary atherosclerosis increased with age in both genders and was greater in men than in women of the same age. Multiple regression analysis revealed that age, systolic blood pressure, serum total cholesterol, and hemoglobin A1C were significant risk factors for men. Age, systolic blood pressure, and waist to hip ratio were risk factors for women. Smoking was not significantly correlated with the grade of coronary atherosclerosis in either gender. Thus, aging, hypertension, hypercholesterolemia, obesity, and glucose intolerance are risk factors for coronary atherosclerosis in recent Japanese populations, and the significance of the metabolic risk factors is different between men and women.

本文言語英語
ページ(範囲)700-708
ページ数9
ジャーナルPathology Research and Practice
205
10
DOI
出版ステータス出版済み - 15-10-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 細胞生物学

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