Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan

M. M.H. Khan, Mitsuru Mori, Fumio Sakauchi, Khandoker Aklimunnessa, Tatsuhiko Kubo, Yoshihisa Fujino, Sadao Suzuki, Shinkan Tokudome, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Kenji WakaiYoshinori Ito, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima, Takashi Shimamoto, Heizo Tanaka, Shigeru Hisamichi, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Teruo Ishibashi, Katsuhiro Fukuda

研究成果: Article

8 引用 (Scopus)

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Objectives: To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. Methods: A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. Results: The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. Conclusions: Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.

元の言語English
ページ(範囲)260-266
ページ数7
ジャーナルAsian Pacific Journal of Cancer Prevention
7
発行部数2
出版物ステータスPublished - 01-01-2006

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Khan, M. M. H., Mori, M., Sakauchi, F., Aklimunnessa, K., Kubo, T., Fujino, Y., Suzuki, S., Tokudome, S., Tamakoshi, A., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Inaba, Y., Hoshiyama, Y., Suzuki, H., Shimizu, H., Toyoshima, H., ... Fukuda, K. (2006). Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan. Asian Pacific Journal of Cancer Prevention, 7(2), 260-266.