Role and mechanism of U1-independent pre-mRNA splicing in the regulation of alternative splicing

Kazuhiro Fukumura, Kunio Inoue

研究成果: Review article査読

8 被引用数 (Scopus)

抄録

In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent pre-mRNA splicing occurs in humans, which contributes to the regulation of alternative splicing. So far it has been reported that several pre-mRNAs were spliced efficiently in a U1 snRNP-independent manner in vitro. Although the molecular mechanism and functional significance of U1-independent pre-mRNA splicing are not well understood, a model of how the 5′ splice site is recognized U1-independently has been proposed. In this review, we first overview a model in which the 5′ splice site is recognized by SR proteins and U6 snRNA. We then discuss our novel model and the functional significance of U1-independent pre-mRNA splicing in the regulation of alternative splicing, based on our recent work.

本文言語English
ジャーナルRNA Biology
6
4
DOI
出版ステータスPublished - 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞生物学

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