Role of CD86 (B7-2) in triggering of antigen-specific IgE antibody response by lipopolysaccharide

G. Z. Jiang, Y. Kato, T. Sugiyama, N. Koide, D. Chakravortty, M. Kawai, M. Fukada, T. Yoshida, T. Yokochi

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The role of CD86 in triggering of ascaris extract-specific IgE antibody response by lipopolysaccharide was studied. The simultaneous administration of anti-CD86 antibody with ascaris extract and lipopolysaccharide prevented the production of IgE antibody response to ascaris extract. CD86+ cells were detected in peritoneal cavities and spleens of mice injected intraperitoneally with lipopolysaccharide. CD86+ cells appeared in peritoneal cavities and spleens eight hours after lipopolysaccharide injection, and they were detectable for a week. CD86+ cells in peritoneal cavities and spleens were mainly surface Ig-positive B-cells and some Ig-negative cells. It was suggested that lipopolysaccharide induced the expression of CD86 mainly on B-cells, and that CD86+ cells induced by lipopolysaccharide injection might play an important role as antigen-presenting cells on triggering of ascaris extract-specific IgE antibody response by lipopolysaccharide. Copyright (C) 1998 Published by Elsevier Science B.V.

本文言語English
ページ(範囲)303-311
ページ数9
ジャーナルFEMS Immunology and Medical Microbiology
21
4
DOI
出版ステータスPublished - 08-1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 微生物学
  • 免疫学
  • 微生物学(医療)
  • 感染症

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