Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-Cadherin-mediated cell-cell adhesion

Shinya Kuroda, Masaki Fukata, Masato Nakagawa, Katsuhiko Fujii, Tomoko Nakamura, Tadashi Ookubo, Ichiro Izawa, Takahiro Nagase, Nobuo Nomura, Hideki Tani, Ikuo Shoji, Yoshiharu Matsuura, Shin Yonehara, Kozo Kaibuchi

研究成果: ジャーナルへの寄稿学術論文査読

437 被引用数 (Scopus)

抄録

The small guanosine triphosphatases (GTPases) Cdc42 and Rac1 regulate E- cadherin-mediated cell-cell adhesion. IQGAP1, a target of Cdc42 and Rac1, was localized with E-cadherin and β-catenin at sites of cell-cell contact in mouse L fibroblasts expressing E-cadherin (EL cells), and interacted with E- cadherin and β-catenin both in vivo and in vitro. IQGAP1 induced the dissociation of α-catenin from a cadherin-catenin complex in vitro and in vivo. Overexpression of IQGAP1 in EL cells, but not in L cells expressing an E-cadherin-α-catenin chimeric protein, resulted in a decrease in E-cadherin- mediated cell-cell, adhesive activity. Thus, IQGAP1, acting downstream of Cdc42 and Rac1, appears to regulate cell-cell adhesion through the cadherin- catenin pathway.

本文言語英語
ページ(範囲)832-835
ページ数4
ジャーナルScience
281
5378
DOI
出版ステータス出版済み - 07-08-1998

All Science Journal Classification (ASJC) codes

  • 一般

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