Role of matrix metalloproteinases in the pathogenesis of childhood gastroenteritis

Yoshiki Kawamura, Kensei Gotoh, Nao Takeuchi, Hiroki Miura, Naoko Nishimura, Takao Ozaki, Tetsushi Yoshikawa

研究成果: Article

抜粋

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the pathogenesis of gastrointestinal diseases, such as rotavirus gastroenteritis (GE). Kinetics of these biomarkers were examined in paired serum samples collected from bacterial enteritis patients with Campylobacter (n=2) and Salmonella (n=4) and viral GE patients with rotavirus (n=27), norovirus (n=25), and adenovirus (n=11). At the time of hospital admission, all viral GE patients demonstrated increased MMP-9 and decreased MMP-2 and TIMP-2 serum levels. In contrast to viral GE patients, serum MMP-9 levels were not elevated at the time of hospital admission but elevated at the time of discharge; serum MMP-2 and TIMP-2 levels were decreased both at the time of admission and discharge in bacterial enteritis patients. Interestingly, the kinetics of serum MMP-2, MMP-9, and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients. Thus, the involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the etiological agent. Further studies are required to verify whether the extent of the bacterial enteritis or age of the patients influences these serum biomarkers.

元の言語English
ページ(範囲)1341-1346
ページ数6
ジャーナルJournal of Medical Virology
88
発行部数8
DOI
出版物ステータスPublished - 01-08-2016

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All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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