Role of microglia in blood pressure and respiratory responses to acute hypoxic exposure in rats

Masashi Yoshizawa, Isato Fukushi, Kotaro Takeda, Yosuke Kono, Yohei Hasebe, Keiichi Koizumi, Keiko Ikeda, Mieczyslaw Pokorski, Takako Toda, Yasumasa Okada

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

Microglia modulate cardiorespiratory activities during chronic hypoxia. It has not been clarified whether microglia are involved in the cardiorespiratory responses to acute hypoxia. Here we investigated this issue by comparing cardiorespiratory responses to two levels of acute hypoxia (13% O2 for 4 min and 7% O2 for 5 min) in conscious unrestrained rats before and after systemic injection of minocycline (MINO), an inhibitor of microglia activation. MINO increased blood pressure but not lung ventilation in the control normoxic condition. Acute hypoxia stimulated cardiorespiratory responses in MINO-untreated rats. MINO failed to significantly affect the magnitude of hypoxia-induced blood pressure elevation. In contrast, MINO tended to suppress the ventilatory responses to hypoxia. We conclude that microglia differentially affect cardiorespiratory regulation depending on the level of blood oxygenation. Microglia suppressively contribute to blood pressure regulation in normoxia but help maintain ventilatory augmentation in hypoxia, which underscores the dichotomy of central regulatory pathways for both systems.

本文言語英語
論文番号26
ジャーナルJournal of Physiological Sciences
72
1
DOI
出版ステータス出版済み - 12-2022

All Science Journal Classification (ASJC) codes

  • 医学一般

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