抄録
This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 1063-1069 |
| ページ数 | 7 |
| ジャーナル | Peptides |
| 巻 | 21 |
| 発行部数 | 7 |
| DOI | |
| 出版物ステータス | Published - 01-07-2000 |
| 外部発表 | Yes |
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All Science Journal Classification (ASJC) codes
- Physiology
- Biochemistry
- Endocrinology
- Cellular and Molecular Neuroscience
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Role of nociceptin systems in learning and memory. / Noda, Yukihiro; Mamiya, Takayoshi; Manabe, Toshiya; Nishi, Miyuki; Takeshima, Hiroshi; Nabeshima, Toshitaka.
：: Peptides, 巻 21, 番号 7, 01.07.2000, p. 1063-1069.研究成果: Review article
TY - JOUR
T1 - Role of nociceptin systems in learning and memory
AU - Noda, Yukihiro
AU - Mamiya, Takayoshi
AU - Manabe, Toshiya
AU - Nishi, Miyuki
AU - Takeshima, Hiroshi
AU - Nabeshima, Toshitaka
PY - 2000/7/1
Y1 - 2000/7/1
N2 - This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.
AB - This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033811693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033811693&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(00)00244-8
DO - 10.1016/S0196-9781(00)00244-8
M3 - Review article
C2 - 10998541
AN - SCOPUS:0033811693
VL - 21
SP - 1063
EP - 1069
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 7
ER -