Role of nociceptin systems in learning and memory

Yukihiro Noda, Takayoshi Mamiya, Toshiya Manabe, Miyuki Nishi, Hiroshi Takeshima, Toshitaka Nabeshima

研究成果: Article査読

42 被引用数 (Scopus)

抄録

This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. Copyright (C) 2000 Elsevier Science Inc.

本文言語English
ページ(範囲)1063-1069
ページ数7
ジャーナルPeptides
21
7
DOI
出版ステータスPublished - 07-2000

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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