Role of peptide leukotrienes in monocrotaline-induced lung disease

S. Ono, M. Noda, T. Tanita, Yasushi Hoshikawa, T. Tabata, S. Ueda, T. Nishimura, Y. Ashino, K. Koike, S. Fujimura

研究成果: Article

抄録

Monocrotaline (MCT) causes lung inflammation and right ventricular hypertrophy associated with lung vascular thickening in rats. We hypothesized that peptide leukotrienes play a role in MCT-induced lung disease, and examined the effect of ONO 1078, a specific antagonist of LTC4, D4 and E4 receptors on MCT-induced right ventricular hypertrophy and on lung vascular thickening. Next, we measured leukotriene C4 (LTC4) levels in the lung tissue of MCT-treated rats. Within 3 weeks after the injection MCT had caused an increase in the ratio of right ventricular weight to left ventricle + septum weight (RV/(LV + S)) and an increase in media wall thickness of the muscular arteries of the lung. In rats given both ONO 1078 and MCT, these changes were significantly less severe than in rats given MCT only. The LTC4 levels in MCT-treated rats were significantly higher than in saline-treated control rats. These results indicate that this antagonist of peptide leukotriene receptors inhibits right ventricular hypertrophy induced by MCT, and suggest a role for peptide leukotrienes in the inflammatory process that contributes to lung vascular remodeling in MCT-treated rats.

元の言語English
ページ(範囲)1415-1420
ページ数6
ジャーナルJapanese Journal of Thoracic Diseases
33
発行部数12
出版物ステータスPublished - 01-12-1995

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Monocrotaline
Leukotrienes
Lung Diseases
Peptides
Right Ventricular Hypertrophy
Lung
Leukotriene C4
Blood Vessels
Leukotriene Antagonists
Weights and Measures
Peptide Receptors
Heart Ventricles
Pneumonia
Arteries

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

これを引用

Ono, S., Noda, M., Tanita, T., Hoshikawa, Y., Tabata, T., Ueda, S., ... Fujimura, S. (1995). Role of peptide leukotrienes in monocrotaline-induced lung disease. Japanese Journal of Thoracic Diseases, 33(12), 1415-1420.
Ono, S. ; Noda, M. ; Tanita, T. ; Hoshikawa, Yasushi ; Tabata, T. ; Ueda, S. ; Nishimura, T. ; Ashino, Y. ; Koike, K. ; Fujimura, S. / Role of peptide leukotrienes in monocrotaline-induced lung disease. :: Japanese Journal of Thoracic Diseases. 1995 ; 巻 33, 番号 12. pp. 1415-1420.
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Ono, S, Noda, M, Tanita, T, Hoshikawa, Y, Tabata, T, Ueda, S, Nishimura, T, Ashino, Y, Koike, K & Fujimura, S 1995, 'Role of peptide leukotrienes in monocrotaline-induced lung disease', Japanese Journal of Thoracic Diseases, 巻. 33, 番号 12, pp. 1415-1420.

Role of peptide leukotrienes in monocrotaline-induced lung disease. / Ono, S.; Noda, M.; Tanita, T.; Hoshikawa, Yasushi; Tabata, T.; Ueda, S.; Nishimura, T.; Ashino, Y.; Koike, K.; Fujimura, S.

:: Japanese Journal of Thoracic Diseases, 巻 33, 番号 12, 01.12.1995, p. 1415-1420.

研究成果: Article

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Ono S, Noda M, Tanita T, Hoshikawa Y, Tabata T, Ueda S その他. Role of peptide leukotrienes in monocrotaline-induced lung disease. Japanese Journal of Thoracic Diseases. 1995 12 1;33(12):1415-1420.