Roles of valproic acid in improving radiation therapy for glioblastoma: A review of literature focusing on clinical evidence

Satoru Ochiai, Yoshihito Nomoto, Yasufumi Yamashita, Yui Watanabe, Yutaka Toyomasu, Tomoko Kawamura, Akinori Takada, Noriko Ii, Shigeki Kobayashi, Hajime Sakuma

研究成果: Short survey査読

13 被引用数 (Scopus)

抄録

Glioblastoma (GBM) is the most common and aggressive type of primary brain neoplasm. The current standard therapy for GBM consists of maximal surgical resection within safe limits, followed by radiation therapy (RT) and chemotherapy with temozolomide. Despite advances in treatment, the prognosis of GBM remains poor. Epileptic seizure is one of the most common symptoms in patients with GBM. Valproic acid (VPA), a histone deacetylase inhibitor, is often used as an anti-epileptic drug in patients with brain neoplasms due to its effectiveness and low toxicity profile. Several in vivo and in vitro studies have indicated that VPA has radiosensitizing effects for gliomas and radioprotective influence on normal brain tissue or hippocampal neurons. The results of several retrospective studies have also indicated potential benefit to improve survival of patients with GBM. Moreover, the promising treatment results of a phase 2 trial of concurrent radiation therapy, temozolomide, and VPA for patients with GBM have been recently reported. The use of VPA in patients with GBM has thus recently receiving more attention. In this article, we review the role of VPA in radiation therapy for GBM, focusing on the clinical evidence.

本文言語English
ページ(範囲)463-466
ページ数4
ジャーナルAsian Pacific Journal of Cancer Prevention
17
2
DOI
出版ステータスPublished - 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 疫学
  • 腫瘍学
  • 公衆衛生学、環境および労働衛生
  • 癌研究

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