Rotavirus vaccine strain transmission by vaccinated infants in the foster home

Hiroki Miura, Yoshiki Kawamura, Ken Sugata, Nozomi Koshiyama, Akiko Yoshikawa, Satoshi Komoto, Koki Taniguchi, Masaru Ihira, Tetsushi Yoshikawa

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)


Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safety in an neonatal intensive care unit. Stool samples were collected from 4 RV vaccinated (160 samples) and 23 unvaccinated (766 samples) infants. RV viral RNA loads were measured using real-time reverse transcription polymerase chain reaction (RT-PCR). RV vaccine strain RNA was persistently detected in stool samples collected from the four vaccine recipients and one unvaccinated infant, but not in the stool samples collected from the 22 other unvaccinated infants. The unvaccinated infant who tested positive for the RV vaccine strain was vaccinated prior to enrollment in this study. The quantitative real-time RT-PCR data revealed a peak viral RNA load 1 week after vaccination followed by a gradual decrease. The current study suggests that RV vaccination may be safe in a close contact environment because there was limited transmission from RV vaccinated to unvaccinated infants. J. Med. Virol. 89:79–84, 2017.

ジャーナルJournal of Medical Virology
出版ステータス出版済み - 01-01-2017

All Science Journal Classification (ASJC) codes

  • ウイルス学
  • 感染症


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