Calcium Pantetheine-S-Sulfonate (PaSSOsCa) is one of the pantothenic acid derivatives. We examined PaSSOaCa inhibition capacity of melanin formation in vitro. For the safety evaluation, we tested PaSSOsCa cream to the fifty one patients with skin diseases by closed patch method. And clinical evaluation of PaSSOsCa was performed in the fifty patients with hyperpigmentation by half side method. Results were as follows; 1. We showed PaSSOsCa inhibition capacity of melanin formation in vitro. 2. PaSSOsCa cream was shown to be safety to the human skin. 3. 10% PaSSOsCa cream lightened the skin hyperpigmentation more than placebo cream.
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