Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: Comparison with diazepam

Kazushige Mizoguchi, Ryuji Ikeda, Hirotaka Shoji, Yayoi Tanaka, Xue Long Jin, Yoshio Kase, Shuichi Takeda, Wakako Maruyama, Takeshi Tabira

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Anxiety is frequently observed in several neuropsychiatric disorders, and stress is thought to precipitate or exacerbate anxiety. In this study, the anxiolytic action of a herbal medicine, saikokaryukotsuboreito, (SRBT) was examined in normal healthy rats using the elevated plus-maze test. Moreover, the improving effect of SRBT on chronic stress-induced anxiety was also examined. Single administration of SRBT did not have anxiolytic action in normal rats. Repeated administration of SRBT significantly improved chronic stress-induced anxiety. On the other hand, single administration of a typical anxiolytic, diazepam, had anxiolytic action in normal rats but repeated administration did not improve chronic stress-induced anxiety. These results suggest that SRBT does not have anxiolytic activity equivalent to that of diazepam but has potency for improving stress-related anxiety. This finding provides information important for the treatment of anxiety.

本文言語English
ページ(範囲)69-74
ページ数6
ジャーナルJournal of Natural Medicines
63
1
DOI
出版ステータスPublished - 01-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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