Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers

Shuji Nomoto, Nobuhiro Haruki, Masashi Kondo, Hiroyuki Konishi, Takao Takahashi, Toshitada Takahashi, Takashi Takahashi

研究成果: Article

190 引用 (Scopus)

抄録

We examined 61 lung cancer case to determine whether alterations of p73, a novel monoallelically expressed p53-like molecule, may be involved in the pathogenesis of lung cancer. Allelic loss at the p73 locus at 1p36.33 was observed in 42% (11 of 26 informative cases), and squamous cell carcinoma tended to carry his lesion most frequently. Somatic mutations in the p73 gene itself, however, were not detected, despite our extensive search. We found interindividual difference in the allelic expression of p73 in normal lung, as well as intertissue variance, even within the same individual, but preferential loss of the expressed allele appeared to be an unlikely mechanism for p73 inactivation. This study, consequently, suggests the presence of an as yet unidentified tumor suppressor gene or genes within the subtelomeric regon of 1p, warranting further studies aimed at its isolation.

元の言語English
ページ(範囲)1380-1383
ページ数4
ジャーナルCancer Research
58
発行部数7
出版物ステータスPublished - 01-04-1998

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Allelic Imbalance
Lung Neoplasms
Mutation
Loss of Heterozygosity
Tumor Suppressor Genes
Genes
Squamous Cell Carcinoma
Alleles
Lung

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Nomoto, S., Haruki, N., Kondo, M., Konishi, H., Takahashi, T., Takahashi, T., & Takahashi, T. (1998). Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Research, 58(7), 1380-1383.
Nomoto, Shuji ; Haruki, Nobuhiro ; Kondo, Masashi ; Konishi, Hiroyuki ; Takahashi, Takao ; Takahashi, Toshitada ; Takahashi, Takashi. / Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. :: Cancer Research. 1998 ; 巻 58, 番号 7. pp. 1380-1383.
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Nomoto, S, Haruki, N, Kondo, M, Konishi, H, Takahashi, T, Takahashi, T & Takahashi, T 1998, 'Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers', Cancer Research, 巻. 58, 番号 7, pp. 1380-1383.

Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. / Nomoto, Shuji; Haruki, Nobuhiro; Kondo, Masashi; Konishi, Hiroyuki; Takahashi, Takao; Takahashi, Toshitada; Takahashi, Takashi.

:: Cancer Research, 巻 58, 番号 7, 01.04.1998, p. 1380-1383.

研究成果: Article

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AU - Takahashi, Takao

AU - Takahashi, Toshitada

AU - Takahashi, Takashi

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AB - We examined 61 lung cancer case to determine whether alterations of p73, a novel monoallelically expressed p53-like molecule, may be involved in the pathogenesis of lung cancer. Allelic loss at the p73 locus at 1p36.33 was observed in 42% (11 of 26 informative cases), and squamous cell carcinoma tended to carry his lesion most frequently. Somatic mutations in the p73 gene itself, however, were not detected, despite our extensive search. We found interindividual difference in the allelic expression of p73 in normal lung, as well as intertissue variance, even within the same individual, but preferential loss of the expressed allele appeared to be an unlikely mechanism for p73 inactivation. This study, consequently, suggests the presence of an as yet unidentified tumor suppressor gene or genes within the subtelomeric regon of 1p, warranting further studies aimed at its isolation.

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Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T, Takahashi T その他. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Research. 1998 4 1;58(7):1380-1383.