Seaweed prevents breast cancer?

Hiroomi Funahashi, Tsuneo Imai, Takahiro Mase, Masanori Sekiya, Kazuki Yokoi, Hiromichi Hayashi, Arihiro Shibata, Takako Hayashi, Mikiko Nishikawa, Namiko Suda, Yatsuka Hibi, Yutaka Mizuno, Kyosuke Tsukamura, Akemi Hayakawa, Seiichi Tanuma

研究成果: Article

110 被引用数 (Scopus)

抄録

To investigate the chemopreventive effects of seaweed on breast cancer, we have been studying the relationship between iodine and breast cancer. We found earlier that the seaweed, wakame, showed a suppressive effect on the proliferation of DMBA (dimethylbenz(a)anthracene)-induced rat mammary tumors, possibly via apoptosis induction. In the present study, powdered mekabu was placed in distilled water, and left to stand for 24 h at 4°C. The filtered supernatant was used as mekabu solution. It showed an extremely strong suppressive effect on rat mammary carcinogenesis when used in daily drinking water, without toxicity. In vitro, mekabu solution strongly induced apoptosis in 3 kinds of human breast cancer cells. These effects were stronger than those of a chemotherapeutic agent widely used to treat human breast cancer. Furthermore, no apoptosis induction was observed in normal human mammary cells. In Japan, mekabu is widely consumed as a safe, inexpensive food. Our results suggest that mekabu has potential for chemoprevention of human breast cancer.

本文言語English
ページ(範囲)483-487
ページ数5
ジャーナルJapanese Journal of Cancer Research
92
5
DOI
出版ステータスPublished - 01-01-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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