Second-line weekly paclitaxel in resistant or relapsed non-small cell lung cancer treated with docetaxel and carboplatin: A multi-center phase II study

Motoshi Ichikawa, Ryujiro Suzuki, Kensuke Kataoka, Yasunobu Noda, Joe Shindoh, Syuichi Matsumoto, Yoshimasa Tanikawa, Kiyoshi Suzuki, Kenji Baba, Yuichiro Shindo, Masashi Kondo, Kazuyoshi Imaizumi, Hiroaki Kume, Yoshinori Hasegawa, Kenzo Takagi, Hiroyuki Taniguchi

研究成果: Article

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We conducted a phase II trial to evaluate the safety and efficacy of weekly paclitaxel in patients with resistant or relapsed non-small cell lung cancer (NSCLC) treated with docetaxel and carboplatin. Thirty-two NSCLC patients at a median age of 58.0 years (range 33-75) were enrolled. The Eastern Cooperative Oncology Group performance status scores (0/1/2) were 18/9/5, respectively. The majority of patients had adenocarcinoma (84%) and stage IV disease (81%). The response rate for the first-line chemotherapy was 28%. Paclitaxel was administered at a dose of 80mg/m2 as an intravenous infusion 60min weekly for 6 consecutive weeks of an 8-week cycle. All patients were assessable for response and toxicity. The median number of cycles administered was two (range 1-8), and the overall response rate was 15.6%. The median survival time (MST) was 10.6 months (95% CI=8.2-12.5), while the 1-year survival rate was 37.5%, and the median progression-free survival was 4.9 months (95% CI=3.0-7.1). Hematological toxicities (grade 3 or 4) were observed in 15 patients (46.9%) with leukopenia, and in 4 (12.5%) with anemia. Non-hematological toxicity was generally mild, though grade 3 anorexia was observed in 3 patients (9.3%). No treatment-related deaths were observed. In conclusion, second-line weekly paclitaxel is effective in NSCLC patients treated with docetaxel plus carboplatin and is associated with a tolerable toxicity profile.

元の言語English
ページ(範囲)319-322
ページ数4
ジャーナルLung Cancer
69
発行部数3
DOI
出版物ステータスPublished - 01-09-2010
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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    Ichikawa, M., Suzuki, R., Kataoka, K., Noda, Y., Shindoh, J., Matsumoto, S., Tanikawa, Y., Suzuki, K., Baba, K., Shindo, Y., Kondo, M., Imaizumi, K., Kume, H., Hasegawa, Y., Takagi, K., & Taniguchi, H. (2010). Second-line weekly paclitaxel in resistant or relapsed non-small cell lung cancer treated with docetaxel and carboplatin: A multi-center phase II study. Lung Cancer, 69(3), 319-322. https://doi.org/10.1016/j.lungcan.2009.11.021