Secretion of ofloxacin into saliva in patients with respiratory tract infection

K. Takagi, T. Hasegawa, K. Yamaki, K. Suzuki, T. Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

5 被引用数 (Scopus)


The simultaneous saliva and plasma ofloxacin (OFLX) concentrations in patients with respiratory tract infection were measured by a microbiological agar-well diffusion assay following a single oral administration of an OFLX preparation. The maximum concentration (C(max)), the time to reach that peak (t(max)) and the elimination half-life of OFLX derived from salivary concentration data were 5.2 ± 0.4 mg/l, 1.9 ± 0.4 h and 3.6 ± 0.5 h, respectively, which were in agreement with those derived from plasma concentration data. The mean saliva-to-plasma concentration ratio (C(s)/C(p)) obtained after the administration of a single oral dose was 1.08 ± 0.05. This was both time-independent and concentration-independent, and it showed a certain relationship with age. A significant correlation was obtained between plasma and saliva concentrations (r = 0.768, p < 0.01). The coefficient of variation for the overall variability was approximately 30.0%. The present results indicate that the secretion of OFLX into saliva may be, at least, due to a passive diffusion mechanism, but a measurement of OFLX concentration in saliva as a guide to dose adjustment would be too wide at odds with plasma concentration to form the basis for a clinical decision.

ジャーナルInternational Journal of Clinical Pharmacology Therapy and Toxicology
出版ステータス出版済み - 1992

All Science Journal Classification (ASJC) codes

  • 毒物学
  • 薬理学(医学)


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