Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis

Shiro Ohgo, Seiji Hasegawa, Yuichi Hasebe, Hiroshi Mizutani, Satoru Nakata, Hirohiko Akamatsu

研究成果: Article査読

4 被引用数 (Scopus)


During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the dermis has not been elucidated. Here, we investigated the effects of factors secreted from senescent fibroblasts on stem cells. We found that senescent human dermal fibroblast (HDF) conditioned medium (CM) significantly enhanced stem cell migration compared with young HDF CM. The senescent HDF CM strongly secreted chemokine ligand 2 (CCL2). Furthermore, CCL2 was found to enhance stem cell migration, and the inhibition of CCR2, a receptor for CCL2, reduced stem cell migration. These results suggest that senescent fibroblasts recruit stem cells by secreting various factors and that the CCL2/CCR2 axis is one of the mechanisms underlying this phenomenon.

ジャーナルExperimental dermatology
出版ステータスPublished - 01-07-2015

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 皮膚病学


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