Sequence and expression of a metabotropic glutamate receptor

Masayuki Masu, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi

研究成果: ジャーナルへの寄稿学術論文査読

1052 被引用数 (Scopus)

抄録

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

本文言語英語
ページ(範囲)760-765
ページ数6
ジャーナルNature
349
6312
DOI
出版ステータス出版済み - 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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