Serotonin 6 receptor gene and mood disorders: Case-control study and meta-analysis

Yasuhisa Fukuo, Taro Kishi, Reiji Yoshimura, Tsuyoshi Kitajima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Wakako Umene-Nakano, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Jun Nakamura, Norio Ozaki, Nakao Iwata

研究成果: Article

15 引用 (Scopus)

抄録

Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.

元の言語English
ページ(範囲)250-255
ページ数6
ジャーナルNeuroscience Research
67
発行部数3
DOI
出版物ステータスPublished - 01-07-2010

Fingerprint

Mood Disorders
Single Nucleotide Polymorphism
Meta-Analysis
Case-Control Studies
Genes
Haplotypes
Population
Signal Transduction
Serotonin
Alleles
Genotype
Pathology
serotonin 6 receptor

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Fukuo, Yasuhisa ; Kishi, Taro ; Yoshimura, Reiji ; Kitajima, Tsuyoshi ; Okochi, Tomo ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Naitoh, Hiroshi ; Umene-Nakano, Wakako ; Inada, Toshiya ; Kunugi, Hiroshi ; Kato, Tadafumi ; Yoshikawa, Takeo ; Ujike, Hiroshi ; Nakamura, Jun ; Ozaki, Norio ; Iwata, Nakao. / Serotonin 6 receptor gene and mood disorders : Case-control study and meta-analysis. :: Neuroscience Research. 2010 ; 巻 67, 番号 3. pp. 250-255.
@article{12067fa30c5e4efab21d23ce2eb2e589,
title = "Serotonin 6 receptor gene and mood disorders: Case-control study and meta-analysis",
abstract = "Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.",
author = "Yasuhisa Fukuo and Taro Kishi and Reiji Yoshimura and Tsuyoshi Kitajima and Tomo Okochi and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Hiroshi Naitoh and Wakako Umene-Nakano and Toshiya Inada and Hiroshi Kunugi and Tadafumi Kato and Takeo Yoshikawa and Hiroshi Ujike and Jun Nakamura and Norio Ozaki and Nakao Iwata",
year = "2010",
month = "7",
day = "1",
doi = "10.1016/j.neures.2010.04.003",
language = "English",
volume = "67",
pages = "250--255",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

Fukuo, Y, Kishi, T, Yoshimura, R, Kitajima, T, Okochi, T, Yamanouchi, Y, Kinoshita, Y, Kawashima, K, Naitoh, H, Umene-Nakano, W, Inada, T, Kunugi, H, Kato, T, Yoshikawa, T, Ujike, H, Nakamura, J, Ozaki, N & Iwata, N 2010, 'Serotonin 6 receptor gene and mood disorders: Case-control study and meta-analysis', Neuroscience Research, 巻. 67, 番号 3, pp. 250-255. https://doi.org/10.1016/j.neures.2010.04.003

Serotonin 6 receptor gene and mood disorders : Case-control study and meta-analysis. / Fukuo, Yasuhisa; Kishi, Taro; Yoshimura, Reiji; Kitajima, Tsuyoshi; Okochi, Tomo; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Naitoh, Hiroshi; Umene-Nakano, Wakako; Inada, Toshiya; Kunugi, Hiroshi; Kato, Tadafumi; Yoshikawa, Takeo; Ujike, Hiroshi; Nakamura, Jun; Ozaki, Norio; Iwata, Nakao.

:: Neuroscience Research, 巻 67, 番号 3, 01.07.2010, p. 250-255.

研究成果: Article

TY - JOUR

T1 - Serotonin 6 receptor gene and mood disorders

T2 - Case-control study and meta-analysis

AU - Fukuo, Yasuhisa

AU - Kishi, Taro

AU - Yoshimura, Reiji

AU - Kitajima, Tsuyoshi

AU - Okochi, Tomo

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Naitoh, Hiroshi

AU - Umene-Nakano, Wakako

AU - Inada, Toshiya

AU - Kunugi, Hiroshi

AU - Kato, Tadafumi

AU - Yoshikawa, Takeo

AU - Ujike, Hiroshi

AU - Nakamura, Jun

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.

AB - Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.

UR - http://www.scopus.com/inward/record.url?scp=77953361787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953361787&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2010.04.003

DO - 10.1016/j.neures.2010.04.003

M3 - Article

C2 - 20394784

AN - SCOPUS:77953361787

VL - 67

SP - 250

EP - 255

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 3

ER -