Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men

Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Yoshiyuki Watanabe, Kyohei Hayashi, Kazuya Mikami, Masahiro Nakao, Tsuneharu Miki, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Tatsuhiko Kubo, Kenji Wakai, Akiko Tamakoshi

研究成果: Article

13 引用 (Scopus)

抄録

Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.

元の言語English
ページ(範囲)1502-1506
ページ数5
ジャーナルJournal of Urology
173
発行部数5
DOI
出版物ステータスPublished - 05-2005

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Carotenoids
Case-Control Studies
Serum
Xanthophylls
Neoplasms
Japan
Tocopherols
Vitamin A
Life Style
Cohort Studies
Smoking

All Science Journal Classification (ASJC) codes

  • Urology

これを引用

Ozasa, Kotaro ; Ito, Yoshinori ; Suzuki, Koji ; Watanabe, Yoshiyuki ; Hayashi, Kyohei ; Mikami, Kazuya ; Nakao, Masahiro ; Miki, Tsuneharu ; Mori, Mitsuru ; Sakauchi, Fumio ; Washio, Masakazu ; Kubo, Tatsuhiko ; Wakai, Kenji ; Tamakoshi, Akiko. / Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men. :: Journal of Urology. 2005 ; 巻 173, 番号 5. pp. 1502-1506.
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title = "Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men",
abstract = "Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95{\%} CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95{\%} CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95{\%} CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.",
author = "Kotaro Ozasa and Yoshinori Ito and Koji Suzuki and Yoshiyuki Watanabe and Kyohei Hayashi and Kazuya Mikami and Masahiro Nakao and Tsuneharu Miki and Mitsuru Mori and Fumio Sakauchi and Masakazu Washio and Tatsuhiko Kubo and Kenji Wakai and Akiko Tamakoshi",
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Ozasa, K, Ito, Y, Suzuki, K, Watanabe, Y, Hayashi, K, Mikami, K, Nakao, M, Miki, T, Mori, M, Sakauchi, F, Washio, M, Kubo, T, Wakai, K & Tamakoshi, A 2005, 'Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men', Journal of Urology, 巻. 173, 番号 5, pp. 1502-1506. https://doi.org/10.1097/01.ju.0000154614.58321.e6

Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men. / Ozasa, Kotaro; Ito, Yoshinori; Suzuki, Koji; Watanabe, Yoshiyuki; Hayashi, Kyohei; Mikami, Kazuya; Nakao, Masahiro; Miki, Tsuneharu; Mori, Mitsuru; Sakauchi, Fumio; Washio, Masakazu; Kubo, Tatsuhiko; Wakai, Kenji; Tamakoshi, Akiko.

:: Journal of Urology, 巻 173, 番号 5, 05.2005, p. 1502-1506.

研究成果: Article

TY - JOUR

T1 - Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men

AU - Ozasa, Kotaro

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Watanabe, Yoshiyuki

AU - Hayashi, Kyohei

AU - Mikami, Kazuya

AU - Nakao, Masahiro

AU - Miki, Tsuneharu

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Washio, Masakazu

AU - Kubo, Tatsuhiko

AU - Wakai, Kenji

AU - Tamakoshi, Akiko

PY - 2005/5

Y1 - 2005/5

N2 - Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.

AB - Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.

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