抄録
Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 1502-1506 |
| ページ数 | 5 |
| ジャーナル | Journal of Urology |
| 巻 | 173 |
| 発行部数 | 5 |
| DOI | |
| 出版物ステータス | Published - 05-2005 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Urology
これを引用
}
Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men. / Ozasa, Kotaro; Ito, Yoshinori; Suzuki, Koji; Watanabe, Yoshiyuki; Hayashi, Kyohei; Mikami, Kazuya; Nakao, Masahiro; Miki, Tsuneharu; Mori, Mitsuru; Sakauchi, Fumio; Washio, Masakazu; Kubo, Tatsuhiko; Wakai, Kenji; Tamakoshi, Akiko.
：: Journal of Urology, 巻 173, 番号 5, 05.2005, p. 1502-1506.研究成果: Article
TY - JOUR
T1 - Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men
AU - Ozasa, Kotaro
AU - Ito, Yoshinori
AU - Suzuki, Koji
AU - Watanabe, Yoshiyuki
AU - Hayashi, Kyohei
AU - Mikami, Kazuya
AU - Nakao, Masahiro
AU - Miki, Tsuneharu
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Washio, Masakazu
AU - Kubo, Tatsuhiko
AU - Wakai, Kenji
AU - Tamakoshi, Akiko
PY - 2005/5
Y1 - 2005/5
N2 - Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.
AB - Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for β-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.
UR - http://www.scopus.com/inward/record.url?scp=20244385813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20244385813&partnerID=8YFLogxK
U2 - 10.1097/01.ju.0000154614.58321.e6
DO - 10.1097/01.ju.0000154614.58321.e6
M3 - Article
C2 - 15821468
AN - SCOPUS:20244385813
VL - 173
SP - 1502
EP - 1506
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 5
ER -