TY - JOUR
T1 - Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people
T2 - The Yakumo study
AU - Tanaka, Satoshi
AU - Ando, Kei
AU - Kobayashi, Kazuyoshi
AU - Hida, Tetsuro
AU - Ito, Kenyu
AU - Tsushima, Mikito
AU - Morozumi, Masayoshi
AU - Machino, Masaaki
AU - Ota, Kyotaro
AU - Seki, Taisuke
AU - Suzuki, Koji
AU - Nishida, Yoshihiro
AU - Ishiguro, Naoki
AU - Hasegawa, Yukiharu
AU - Imagama, Shiro
N1 - Funding Information:
We are grateful to the staff of the Comprehensive Health Care Program held in Yakumo, Hokkaido and Ms. Marie Miyazaki and Ms. Hiroko Ino of Nagoya University for their assistance throughout this study.
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.
AB - Objectives: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. Methods: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement. A comparative study was conducted in participants with and without LS risk and in subgroups aged <60 and ≥60 years. Results: No significant difference was found in the serum cystatin C level in subgroups aged <60 years and without LS risk. However, it was significantly higher in subjects with LS risk and aged ≥60 years. The area under the curve of the serum cystatin C level for LS risk was 0.824. Conclusion: The serum cystatin C level is significantly related to LS risk and can be an early predictor. In middle-aged and elderly people with high serum cystatin C levels, it is strongly recommended to enforce LS risk test and intervention.
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U2 - 10.1080/14397595.2018.1441675
DO - 10.1080/14397595.2018.1441675
M3 - Article
C2 - 29442538
AN - SCOPUS:85042945271
VL - 28
SP - 1035
EP - 1040
JO - Modern Rheumatology
JF - Modern Rheumatology
SN - 1439-7595
IS - 6
ER -