Serum hepatitis C virus RNA level as a predictor of subsequent response to interferon‐α therapy in Japanese patients with chronic hepatitis C

Etsuro Onto, Masashi Mizokami, Tatsunori Nakano, Hisahiro Terashima, Osamu Nojiri, Kenji Sakakibara, Makoto Mizuno, Masataka Ogino, Makoto Nakamura, Yukoh Matsumoto, Ken‐Ichi ‐I Miyata, Johnson Y.N. Lau

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Serum hepatitis C virus (HCV) RNA level has been shown to be a good predictor of subsequent response to interferon‐α (IFN) therapy in US patients in whom genotype 1a/1b are both predominant. To determine whether serum HCV RNA level is a predictor of subsequent response to IFN in Japanese patients or not, appropriately collected pre‐IFN therapy serum samples from 35 Japanese patients with chronic HCV infection were studied. Serum HCV RNA level and HCV genotype were determined and correlated with the subsequent response to IFN. Response to IFN was defined by serum alanine transaminase level: complete and sustained response (n = 15), complete response followed by relapse (n = 10), and no response (n = 10). Patients with complete and sustained response had lower pre‐IFN serum HCV RNA level (median: RT‐PCR+, bDNA‐) compared to the complete response to relapse group (median: 5.25 × 106 genome equivalent/ml [eq/ml], P < 0.001) and the no response group (median: 10.63 × 106 eq/ml, P < 0.001). Seven (46.7%) of the complete and sustained response patients had HCV genotype 2a and three patients had a mixture of genotypes 1b and 2a. In contrast, all 10 patients in the complete response to relapse group had genotype 1b whereas 8 of 10 patients in the non‐response group had genotype 1b and 2 had genotype 2b. The patients with HCV genotype 2a had lower serum HCV RNA level than those with 1b (P = 0.002). When the HCV viremia were controlled by stratifying them into < and > 106 eq/ml, patients with genotype 1 had a similar complete and sustained response rate compared to genotype 2. These data indicated that pre‐IFN serum HCV RNA is also a good predictor of subsequent complete and sustained response in Japanese patients with chronic HCV infection. © 1994 Wiley‐Liss, Inc.

本文言語English
ページ(範囲)410-414
ページ数5
ジャーナルJournal of Medical Virology
44
4
DOI
出版ステータスPublished - 12-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • ウイルス学
  • 感染症

フィンガープリント

「Serum hepatitis C virus RNA level as a predictor of subsequent response to interferon‐α therapy in Japanese patients with chronic hepatitis C」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル