抄録
Aims: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1279-1281 |
ページ数 | 3 |
ジャーナル | Diabetic Medicine |
巻 | 24 |
号 | 11 |
DOI | |
出版ステータス | 出版済み - 11-2007 |
All Science Journal Classification (ASJC) codes
- 内科学
- 内分泌学、糖尿病および代謝内科学
- 内分泌学