TY - JOUR
T1 - Severity of coronary atherosclerosis correlates with the respiratory component of heart rate variability
AU - Hayano, Junichiro
AU - Yamada, Akira
AU - Mukai, Seiji
AU - Sakakibara, Yusaku
AU - Yamada, Masami
AU - Ohte, Nobuyuki
AU - Hashimoto, Takeshi
AU - Fujinami, Takao
AU - Takata, Kazuyuki
N1 - Funding Information:
From the Third Department Medical School and Toyota This study was funded in part Scientists no. 02770499 from ture, Japan. Received for publication of Internal Medicine, College of Technology. by Grant-in-Aid for Encouragement the Ministry Education, Science
PY - 1991/4
Y1 - 1991/4
N2 - Decreased vagal activity is frequently observed in coronary artery disease, but the mechanism of this association is unknown. We investigated cardiac autonomic function by relating heart rate spectral components to clinical and angiographic findings in 80 patients who were undergoing coronary angiography. The age- and sex-adjusted magnitude of the respiratory spectral component, which is an index of cardiac vagal tone, showed a significant negative correlation with the extent of coronary atheromatosis (r = -0.43, p < 0.0001) and a less significant negative correlation with the severity of coronary stenosis (r = -0.30, p = 0.0070). These relationships were independent of previous myocardial infarction and of left ventricular function. Stepwise regression analysis showed that the respiratory spectral component contributed to atheromatosis independently of established coronary risk factors (partial R2 = 9.4%, p = 0.002), but not to stenosis. Our results support the hypothesis that decreased cardiac vagal activity is associated with an increased risk of coronary atherosclerosis.
AB - Decreased vagal activity is frequently observed in coronary artery disease, but the mechanism of this association is unknown. We investigated cardiac autonomic function by relating heart rate spectral components to clinical and angiographic findings in 80 patients who were undergoing coronary angiography. The age- and sex-adjusted magnitude of the respiratory spectral component, which is an index of cardiac vagal tone, showed a significant negative correlation with the extent of coronary atheromatosis (r = -0.43, p < 0.0001) and a less significant negative correlation with the severity of coronary stenosis (r = -0.30, p = 0.0070). These relationships were independent of previous myocardial infarction and of left ventricular function. Stepwise regression analysis showed that the respiratory spectral component contributed to atheromatosis independently of established coronary risk factors (partial R2 = 9.4%, p = 0.002), but not to stenosis. Our results support the hypothesis that decreased cardiac vagal activity is associated with an increased risk of coronary atherosclerosis.
UR - https://www.scopus.com/pages/publications/0026082770
UR - https://www.scopus.com/pages/publications/0026082770#tab=citedBy
U2 - 10.1016/0002-8703(91)90664-4
DO - 10.1016/0002-8703(91)90664-4
M3 - Article
C2 - 2008828
AN - SCOPUS:0026082770
SN - 0002-8703
VL - 121
SP - 1070
EP - 1079
JO - American Heart Journal
JF - American Heart Journal
IS - 4 PART 1
ER -